Re-targeting of human lymphocytes expressing the T-cell receptor gamma/delta to ovarian carcinoma cells by the use of bispecific monoclonal antibodies.

@article{Ferrini1989RetargetingOH,
  title={Re-targeting of human lymphocytes expressing the T-cell receptor gamma/delta to ovarian carcinoma cells by the use of bispecific monoclonal antibodies.},
  author={Silvano Ferrini and Ignazia Prigione and Serafina Mammoliti and Maria Ines Colnaghi and Sylvie M{\'e}nard and Alessandro Moretta and Lorenzo Moretta},
  journal={International journal of cancer},
  year={1989},
  volume={44 2},
  pages={245-50}
}
TcR gamma/delta+ lymphocytes represent a small subset homogeneously composed of cytolytic T cells displaying unique motility and homing properties. Since the lytic machinery of these cells can be efficiently triggered by monoclonal antibodies (MAbs) directed to the TcR gamma/delta, such MAbs were used for the construction of bispecific MAbs in conjunction with an MAb specific for ovarian carcinoma cells. Hybrid hybridomas were obtained by fusing the Mov19 MAb (IgG2a)-producing hybridoma with… CONTINUE READING