Re-programming DNA-binding specificity in zinc finger proteins for targeting unique address in a genome

  title={Re-programming DNA-binding specificity in zinc finger proteins for targeting unique address in a genome},
  author={Abhinav Grover and A B Pande and Krishna Choudhary and Kriti Gupta and Durai Sundar},
  journal={Systems and Synthetic Biology},
Recent studies provide a glimpse of future potential therapeutic applications of custom-designed zinc finger proteins in achieving highly specific genomic manipulation. Custom-design of zinc finger proteins with tailor-made specificity is currently limited by the availability of information on recognition helices for all possible DNA targets. However, recent advances suggest that a combination of design and selection method is best suited to identify custom zinc finger DNA-binding proteins for… 
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