Re-infection of the prion from the scrapie-infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c

@inproceedings{Xiao2016ReinfectionOT,
  title={Re-infection of the prion from the scrapie-infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c},
  author={Kang Xiao and Bao-yun Zhang and Xiao-mei Zhang and Jing Wang and Cao Chen and Li-na Chen and Yan Chun Lv and Qi Shi and Xiao-Ping Dong},
  booktitle={International journal of molecular medicine},
  year={2016}
}
It is well known that the SMB-S15 cell line was originally established by cultures from the brains of mice affected by the Chandler scrapie strain, and this cell line may express PrPSc permanently. However, the infectivity of the S15-derived prions on experimental animals has not yet been well documented. In the present study, the cell lysates of SMB-S15 were intracerebrally inoculated into three different strains of mice, namely C57BL/6, Balb/c and CD1. Prion protein (PRNP) gene sequencing… CONTINUE READING

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