Re-expression of major histocompatibility complex (MHC) class I molecules on malignant tumor cells and its effect on host-tumor interaction.

@article{Hui1989ReexpressionOM,
  title={Re-expression of major histocompatibility complex (MHC) class I molecules on malignant tumor cells and its effect on host-tumor interaction.},
  author={Kam Man Hui},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={1989},
  volume={11 1},
  pages={22-6}
}
  • Kam Man Hui
  • Published 1989 in
    BioEssays : news and reviews in molecular…
The expression of products encoded by the major histocompatibility complex (MHC) on tumor cells has recently been studied extensively. It has been found that many malignant tumor cells have their MHC antigens 'switched-off' but that these antigens are re-expressed following DNA-mediated gene transfer, with increased tumor immunogenicity as a result and the consequence that these 'transformed' tumor cells are rejected in vivo. This review will discuss approaches that have been taken to induce… CONTINUE READING

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