Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth

@article{Mao2004ReexpressionOT,
  title={Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth},
  author={Xinliang Mao and Eric P. Seidlitz and Ray Truant and Mary Anne Hitt and Hara P. Ghosh},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={5632-5642}
}
The TSLC1 tumor-suppressor gene is silenced in a number of human cancer tissues and cell lines, including lung, prostate, liver, stomach, pancreatic, and breast cancers. Expression of TSLC1 in a non-small-cell lung cancer (NSCLC) cell line A549 suppresses tumorigenicity in nude mice. However, the molecular mechanism of TSLC1 action is not yet elucidated. In the present study, we show that the expression of TSLC1 from a recombinant adenovirus vector (Ad-TSLC1) inhibited cell proliferation and… CONTINUE READING

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