Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis?

@article{Charles2002ReexpressionOP,
  title={Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis?},
  author={Perrine Charles and Richard Reynolds and Danielle Seilhean and Genevi{\`e}ve N. Rougon and Marie St{\'e}phane Aigrot and Adam Niezgoda and Bernard Zalc and Catherine Lubetzki},
  journal={Brain : a journal of neurology},
  year={2002},
  volume={125 Pt 9},
  pages={1972-9}
}
Multiple sclerosis is affecting approximately 1 out of every 1000 individuals in the western world. After axons are denuded of myelin in the early stages of the disease, remyelination occurs, but eventually this process fails, and permanent disability is the result. During development, the polysialylated form of the neural cell adhesion molecule NCAM, PSA-NCAM, is expressed at the axonal surface and acts as a negative regulator of myelination, presumably by preventing myelin-forming cells from… CONTINUE READING