Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination

@article{Hochmeister2012ReexpressionON,
  title={Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination},
  author={Sonja Hochmeister and Matthias Romauch and Jan Bauer and Thomas Seifert-Held and Robert Weissert and Christopher Linington and H. P. Hartung and Fruzsina Fazekas and Maria K. Storch},
  journal={Experimental Neurology},
  year={2012},
  volume={237},
  pages={70-77}
}
The cell adhesion molecule N-cadherin is involved in several processes during central nervous system development, but also in certain pathologic conditions in the adult brain, including tumorigenesis and Alzheimer's disease. N-cadherin function in inflammatory demyelinating disease has so far not been investigated. In vitro studies suggest a role of N-cadherin in myelination; on the other hand N-cadherin has been implicated in the formation of the glial scar, which is believed to impede… 
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References

SHOWING 1-10 OF 60 REFERENCES
Differential expression of sonic hedgehog immunoreactivity during lesion evolution in autoimmune encephalomyelitis.
TLDR
A role of Shh signaling in facilitating remyelination in immune-mediated demyelinating disease remains still uncertain, but findings may imply that the exact molecular mechanisms of the Shh-signaling pathway in experimental autoimmune encephalomyelitis are yet to be determined.
Notch1 and its ligand Jagged1 are present in remyelination in a T-cell- and antibody-mediated model of inflammatory demyelination
TLDR
It is unlikely, at least in the paradigm of MOG-EAE, that Notch signaling is responsible for a failure of remyelination, as constituents of the Notch pathway are expressed in remyELination in an animal model of T-cell- and antibody-mediated CNS demyelinated.
Expression of cadherin and CSF dissemination in malignant astrocytic tumors
TLDR
It is concluded that decreased expression of N-cadherin at the time of recurrence correlates with dissemination in malignant astrocytic tumors.
N-cadherin expression and function in cultured oligodendrocytes.
TLDR
The results suggest that N-cadherin is not likely to function predominantly as a substrate that stimulates migration of O-2A progenitors, but may be more important in initiating early oligodendrocyte-axon interactions that promote the process of myelination.
Mechanisms of demyelination and tissue destruction in multiple sclerosis
  • H. Lassmann
  • Medicine
    Clinical Neurology and Neurosurgery
  • 2002
TLDR
The situation with MS pathogenesis may be more complex than previously thought, as therapeutic strategies that modulate or dampen the T-cell mediated immune response should cure the affected patients.
N-cadherin at the glial scar in the rat
TLDR
These data are the first to demonstrate that N-cadherin plays a prominent role in the response of astrocytes to injury, including the formation and maintenance of the glial scar.
Correlation of N-cadherin expression in high grade gliomas with tissue invasion
TLDR
N-cadherin levels are important in the malignant behavior of gliomas, and may serve as a prognostic indicator for patients with high-gradegliomas.
Immunohistochemical and biochemical analysis of N‐cadherin expression during CNS development
TLDR
While, in general, the program of N‐cadherin expression is similar in the retina and the brain, certain structures unique to the eye and brain express locally high or low levels of this adhesion protein.
Monocyte/macrophage differentiation in early multiple sclerosis lesions
TLDR
Findings indicate a differentiated pattern of macrophage activation in MS lesions and allow the staging of demyelinating lesions in routinely fixed and paraffin‐embedded tissue.
MHC Gene Related Effects on Microglia and Macrophages in Experimental Autoimmune Encephalomyelitis Determine the Extent of Axonal Injury
TLDR
A comparison of lesions showed that in spite of a similar extent of demyelination, axonal injury was significantly less in microglia compared to macrophage dominated lesions, which document a genetic influence of the MHC‐region on the relative contribution of macrophages versus micro glia in the pathogenesis of EAE.
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