Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion.

@article{Latini2008ReexpressionOA,
  title={Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion.},
  author={Fl{\'a}via Roche Moreira Latini and Jefferson Pessoa Hemerly and Gisele Oler and Gregory Joseph Riggins and Janete M Cerutti},
  journal={Endocrine-related cancer},
  year={2008},
  volume={15 3},
  pages={787-99}
}
Loss of ABI gene family member 3-binding protein (ABI3BP) expression may be functionally involved in the pathogenesis of cancer. Previous reports have indicated a loss of expression in lung cancer and a presumed role in inducing cellular senescence. We show here that ABI3BP expression is significantly decreased in most malignant thyroid tumors of all types. To better understand ABI3BP's role, we created a model by re-expressing ABI3BP in two thyroid cancer cell lines. Re-expression of ABI3BP in… CONTINUE READING

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