Re-expansion pulmonary edema. A potential role for free radicals in its pathogenesis.

  title={Re-expansion pulmonary edema. A potential role for free radicals in its pathogenesis.},
  author={Robert Max Jackson and C F Veal and Cornelius B. Alexander and A L Brannen and Jack D. Fulmer},
  journal={The American review of respiratory disease},
  volume={137 5},
Re-expansion pulmonary edema (RPE) has been attributed to decreased lung interstitial pressures from a variety of mechanisms. Because some recent studies have implicated mechanisms that increase microvascular permeability in RPE, we tested whether the edema were due to free radical generation during re-expansion and reoxygenation of the collapsed lung. We used a rabbit model of RPE to test the effects of intracellular (dimethylthiourea) or extracellular (catalase) oxygen metabolite scavengers… CONTINUE READING


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