Re-examination of some of the Framingham blood-pressure data.

@article{Anderson1978ReexaminationOS,
  title={Re-examination of some of the Framingham blood-pressure data.},
  author={Terence W. Anderson},
  journal={Lancet},
  year={1978},
  volume={2 8100},
  pages={1139-41}
}
Mathematical smoothing of data for the Framingham study leads to the conclusion that there is no threshold of normality for blood-pressure. A reasonable therapeutic goal might be "the lower the better". However, examination of the unsmoothed Framingham data indicates that while systolic pressures fit this no-threshold model reasonably well, changes in diastolic pressure below about 90 mm Hg have little or no prognostic significance. The poor fit of the diastolic points to the no-threshold model… CONTINUE READING

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