Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotinin era.

@article{Koster2011ReevaluationOT,
  title={Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotinin era.},
  author={Andreas A Koster and Uwe Schirmer},
  journal={Current opinion in anaesthesiology},
  year={2011},
  volume={24 1},
  pages={92-7}
}
PURPOSE OF REVIEW Hemorrhage, transfusions and the need for re-exploration can have a detrimental effect on patient outcome in cardiac surgery. With the suspension of aprotinin from the market, only the antifibrinolytics tranexamic acid and epsilon-aminocaproic acid (EACA) are left as pharmacological options to reduce hemostatic activation and associated bleeding complications. In light of the aprotinin story, the need for large independent safety studies has become evident. The current review… CONTINUE READING