Re-evaluation of the relationship between the positive inotropic effect of ouabain and its inhibitory effect on (Na+ + K+)-dependent adenosine triphosphatase in rabbit and dog hearts.

@article{Huang1979ReevaluationOT,
  title={Re-evaluation of the relationship between the positive inotropic effect of ouabain and its inhibitory effect on (Na+ + K+)-dependent adenosine triphosphatase in rabbit and dog hearts.},
  author={Wen Huan Huang and H. M. Rhee and T. H. Chiu and Amir Hossein Askari},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1979},
  volume={211 3},
  pages={571-82}
}
Previous studies have shown that in the ouabain-exposed rabbit heart, although positive inotropy and inhibition of (Na+ + K+)-dependent adenosine triphosphatase are induced concomitantly, the extent of inhibition of the enzyme remains constant when positive inotropy is washed out; and in the dog heart, if positive inotropy without arrhythmias is induced by… CONTINUE READING