Re-evaluation of the Immunological Big Bang

Abstract

Classically the immunological 'Big Bang' of adaptive immunity was believed to have resulted from the insertion of a transposon into an immunoglobulin superfamily gene member, initiating antigen receptor gene rearrangement via the RAG recombinase in an ancestor of jawed vertebrates. However, the discovery of a second, convergent adaptive immune system in… (More)
DOI: 10.1016/j.cub.2014.09.070

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