Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats

@article{MaronaLewicka2002ReevaluationOL,
  title={Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats},
  author={Danuta Marona-Lewicka and Deborah M. Kurrasch-Orbaugh and Jennifer R. Selken and Medhane G. Cumbay and Joshua G. Lisnicchia and David E. Nichols},
  journal={Psychopharmacology},
  year={2002},
  volume={164},
  pages={93-107}
}
Abstract Rationale. There is substantial evidence that lisuride can produce effects linked to 5-HT1A receptor occupancy. Nevertheless, this action has generally been ignored in the mechanism of action of lisuride, in favor of an exclusive role for dopamine receptors in considering its antiparkinsonian effects, or an exclusive role of 5-HT2A/2C receptor activation in hallucinogenesis. These conclusions are surprising when one considers that the potent interaction of lisuride with 5-HT1A… 

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