Re-evaluation of fibrogenic cytokines in lung fibrosis.

  title={Re-evaluation of fibrogenic cytokines in lung fibrosis.},
  author={Margaret M. Kelly and Martin Kolb and Phillipe Bonniaud and Jack Gauldie},
  journal={Current pharmaceutical design},
  volume={9 1},
Idiopathic Pulmonary Fibrosis (IPF) is a chronic interstitial lung disease which results in end-stage fibrosis. The pathogenesis is believed to be related to a dysregulation in cross-talk between inflammatory and structural cells, mediated by various cytokines, chemokines and growth factors, which are responsible for the maintenance of tissue homeostasis and which coordinate the response to injury. The large number of mediators involved and the complexity of their interaction makes it difficult… CONTINUE READING