Re-establishing the regenerative potential of central nervous system axons in postnatal mice.

@article{Cho2005ReestablishingTR,
  title={Re-establishing the regenerative potential of central nervous system axons in postnatal mice.},
  author={Kin-Sang Cho and Liu Yang and Bin Lu and Hong Feng Ma and Xizhong A. Huang and Milos Pekny and Dong Feng Chen},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 5},
  pages={863-72}
}
At a certain point in development, axons in the mammalian central nervous system lose their ability to regenerate after injury. Using the optic nerve model, we show that this growth failure coincides with two developmental events: the loss of Bcl-2 expression by neurons and the maturation of astrocytes. Before postnatal day 4, when astrocytes are immature, overexpression of Bcl-2 alone supported robust and rapid optic nerve regeneration over long distances, leading to innervation of brain… CONTINUE READING

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