Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus.

@article{Ledda2017ReemergenceOM,
  title={Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus.},
  author={Alice Ledda and James R. Price and Kevin D. Cole and Martin J. Llewelyn and Angela M. Kearns and Derrick W. Crook and John Paul and Xavier Didelot},
  journal={The Journal of antimicrobial chemotherapy},
  year={2017},
  volume={72 5},
  pages={1285-1288}
}
Objectives MRSA is a leading cause of hospital-associated infection. Acquired resistance is encoded by the mecA gene or its homologue mecC , but little is known about the evolutionary dynamics involved in gain and loss of resistance. The objective of this study was to obtain an expanded understanding of Staphylococcus aureus methicillin resistance microevolution in vivo , by focusing on a single lineage. Methods We compared the whole-genome sequences of 231 isolates from a single epidemic… CONTINUE READING
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