Re-emergence of amantadine-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt.

@article{ElShesheny2016ReemergenceOA,
  title={Re-emergence of amantadine-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt.},
  author={Rabeh El-Shesheny and Ola Bagato and Ahmed M. Kandeil and Ahmed Mostafa and Sara H Mahmoud and Hamdi M Hassanneen and Richard R. J. Webby and Mohamed Ahmed Mohamed Ali and Ghazi Kayali},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2016},
  volume={46},
  pages={102-109}
}
Highly pathogenic avian influenza (HPAI) H5N1 virus continues to undergo substantial evolution. Emergence of antiviral resistance among H5N1 avian influenza viruses is a major challenge in the control of pandemic influenza. Numerous studies have focused on the genetic and evolutionary dynamics of the hemagglutinin and neuraminidase genes; however, studies on the susceptibility of HPAI H5N1 viruses to amantadine and genetic diversity of the matrix (M) gene are limited. Accordingly, we studied… CONTINUE READING
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