Re-appraisal of the role of histamine in carrageenan-induced paw oedema.

@article{AlHaboubi1983ReappraisalOT,
  title={Re-appraisal of the role of histamine in carrageenan-induced paw oedema.},
  author={H. A. Al-Haboubi and I. J. Zeitlin},
  journal={European journal of pharmacology},
  year={1983},
  volume={88 2-3},
  pages={
          169-76
        }
}

Effect of neonatal treatment with capsaicin on carrageenan-induced paw oedema in the rat

The increased and prolonged inflammatory response to carrageenan in capsaicin-treated rats may be explained by an enhanced release of histamine from mast cells and may also reflect a ‘trophic disorder of the denervated skin’.

Evaluation of the central and peripheral effects of doxepin on carrageenan-induced inflammatory paw edema in rat

Although the exact mechanism of the anti-inflammatory effect of doxepin is not clear, it seems that reduced leukocyte migration and pro-inflammatory cytokines play important role in its anti- inflammation effect.

The mechanism of the anti-inflammatory effect of turpentine in the rat

It is suggested that the main factor involved is a decrease in leucocyte accumulation into the exudates, which reduced the carrageenan-oedema in normal as well as in adrenalectomized rats.

Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

The antiinflammatory effect of nabilone is shown and that of palmitoylethanolamide is confirmed indicating that these actions are mediated by an uncharacterized CB2‐like cannabinoid receptor.

Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats.

  • M. Ortiz
  • Biology, Medicine
    Canadian journal of physiology and pharmacology
  • 2017
The data suggest that the diclofenac-pyrilamine combinations can interact at the systemic and local peripheral levels, thereby offering a therapeutic alternative for the clinical management of inflammatory pain.
...

References

SHOWING 1-10 OF 20 REFERENCES

Mediators of the inflammation induced in the rat paw by carrageenin

It was concluded that kinins and 5‐HT contributed significantly to oedema formation during this period, and mepyramine and methysergide, at the doses used in the carrageenin experiments, completely antagonized histamine and5‐HT, respectively, and did not affect the skin responses of bradykinin.

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

  • C. WinterE. RisleyG. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.

Biphasic development of carrageenin edema in rats.

The discovery that carrageenin was charred by heat treatment at 130°C for 16 hr, it elicited the full first phase edema volume without subsequent development of the second phase indicates that the secondphase is not a consequence of processes initiated during the first phase but is dependent on the structural integrity of the irritant molecule.

Further studies on carrageenan‐induced pleurisy in rats

Intrapleural injection of carrageenan after complement depletion produced a reduced migration of polymorphonuclear cells and also a reduction in volume of exudate, and prostaglandins remained unaffected by this treatment.

ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDO-METHACIN, 1-(p-CHLOROBENZOYL)-5-METHOXY-2-METHYL-INDOLE-3-ACETIC ACID

The compound is an active antipyretic drug, with potency 10 to 20 times that of phenylbutazone, and when used in conjunction with a steroid, the action of the latter is enhanced.

SOME DETAILS OF THE INFLAMMATIONS CAUSED BY YEAST AND CARRAGEENIN (WITH APPENDIX ON KINETICS OF THE REACTION)

An improved assay method for inflammation in the rat’s foot is described, and an equation was found that enables prediction of the swelling as a function of time and dosage of Bradykinin.

EFFECTS OF INFLAMMATORY AGENTS ON ENDOTHELIAL LYSOSOMAL FRAGILITY AND THEIR INHIBITION BY ANTIINFLAMMATORY DRUGS

  • J. Yoffe
  • Medicine, Biology
    British journal of pharmacology
  • 1981
Pretreatment with indomethacin, hydrocortisone, ibuprofen and sodium salicylate caused a dose‐dependent inhibition of histamine‐induced fragility and Bradykinin decreased fragility.

Production of Arthritis in the Rabbit by the Local Injection of the Mucopolysaccharide Caragheenin

  • D. Gardner
  • Biology, Medicine
    Annals of the rheumatic diseases
  • 1960
Experiments have been made with the sulphated mucopolysaccharide caragheenin, a substance obtained from the Irish moss Chondrus crispus, or from Scottish seaweed, which appears to offer certain advantages as a stimulating material in the experimental study of arthritis.