Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors


The controlled and specific re-activation of endogenous tumor suppressors in cancer cells represents an important therapeutic strategy to block tumor growth and subsequent progression. Other than ectopic delivery of tumor suppressor-encoded cDNA, there are no therapeutic tools able to specifically re-activate tumor suppressor genes that are silenced in… (More)
DOI: 10.1038/sj.onc.1210072

3 Figures and Tables


  • Presentations referencing similar topics