Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors

Abstract

The controlled and specific re-activation of endogenous tumor suppressors in cancer cells represents an important therapeutic strategy to block tumor growth and subsequent progression. Other than ectopic delivery of tumor suppressor-encoded cDNA, there are no therapeutic tools able to specifically re-activate tumor suppressor genes that are silenced in… (More)
DOI: 10.1038/sj.onc.1210072

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