Re: β-catenin is essential for Müllerian duct regression during male sexual differentiation.

  title={Re: β-catenin is essential for M{\"u}llerian duct regression during male sexual differentiation.},
  author={Anthony Atala},
  volume={138 10},
During male sexual differentiation, the transforming growth factor-β (TGF-β) signaling molecule anti-Müllerian hormone (AMH; also known as Müllerian inhibiting substance, MIS) is secreted by the fetal testes and induces regression of the Müllerian ducts, the primordia of the female reproductive tract organs. Currently, the molecular identity of downstream events regulated by the AMH signaling pathway remains unclear. We found that male-specific Wnt4 expression in mouse Müllerian duct mesenchyme… CONTINUE READING