Re: "Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs".


Case-control designs that use population controls are compared with those that use controls selected from their relatives (i.e., siblings, cousins, or "pseudosibs" based on parental alleles) for estimating the effect of candidate genes and gene-environment interactions. The authors first evaluate the asymptotic bias in relative risk estimates resulting from… (More)

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