Rds3p is required for stable U2 snRNP recruitment to the splicing apparatus.

@article{Wang2003Rds3pIR,
  title={Rds3p is required for stable U2 snRNP recruitment to the splicing apparatus.},
  author={Qiang Wang and Brian C. Rymond},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 20},
  pages={7339-49}
}
Rds3p is a well-conserved 12-kDa protein with five CxxC zinc fingers that has been implicated in the activation of certain drug transport genes and in the pre-mRNA splicing pathway. Here we show that Rds3p resides in the yeast spliceosome and is essential for splicing in vitro. Rds3p purified from yeast stably associates with at least five U2 snRNP proteins, Cus1p, Hsh49p, Hsh155p, Rse1p, and Ist3p/Snu17p, and with the Yra1p RNA export factor. A mutation upstream of the first Rds3p zinc finger… CONTINUE READING
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