Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia.

Abstract

Periventricular heterotopia (PH) is a cortical malformation characterized by aggregation of neurons lining the lateral ventricles due to abnormal neuronal migration. The molecular mechanism underlying the pathogenesis of PH is unclear. Here we show that Regulators of calcineurin 1 (Rcan1), a Down syndrome-related gene, plays an important role in radial… (More)
DOI: 10.1523/JNEUROSCI.1003-14.2015

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@article{Li2015Rcan1DI, title={Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia.}, author={Yang Li and Jie Wang and Yang Zhou and Dan Li and Zhi-qi Xiong}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2015}, volume={35 2}, pages={610-20} }