Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges

@article{Lovci2013RbfoxPR,
  title={Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges},
  author={Michael T. Lovci and Dana Ghanem and Henry L Marr and Justin M Arnold and Sherry L. Gee and M. Gonz{\'a}lez De La Parra and Tiffany Y. Liang and Thomas J. Stark and Lauren T. Gehman and Shawn Hoon and Katlin Brauer Massirer and Gabriel A. Pratt and Douglas L. Black and Joe W. Gray and J. G. Conboy and Gene W. Yeo},
  journal={Nature Structural &Molecular Biology},
  year={2013},
  volume={20},
  pages={1434-1442}
}
Alternative splicing (AS) enables programmed diversity of gene expression across tissues and development. We show here that binding in distal intronic regions (>500 nucleotides (nt) from any exon) by Rbfox splicing factors important in development is extensive and is an active mode of splicing regulation. Similarly to exon-proximal sites, distal sites contain evolutionarily conserved GCATG sequences and are associated with AS activation and repression upon modulation of Rbfox abundance in human… CONTINUE READING
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