RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.

@article{Nicolas2000RbAp48BT,
  title={RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.},
  author={Estelle Nicolas and V{\'i}ctor Morales and Laura Magnaghi-Jaulin and Annick Harel-Bellan and H{\'e}l{\`e}ne Richard-Foy and Didier Trouche},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 13},
  pages={9797-804}
}
The retinoblastoma susceptibility gene product, the Rb protein, is a key regulator of mammalian cell proliferation. One of the major targets of Rb is the S phase inducing E2F transcription factor. Once bound to E2F, Rb represses the expression of E2F-regulated genes. Transcriptional repression by Rb is believed to be crucial for the proper control of cell growth. Recently, we and others showed that Rb represses transcription through the recruitment of a histone deacetylase. Interestingly, we… CONTINUE READING

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