Rb1 postconditioning attenuates liver warm ischemia-reperfusion injury through ROS-NO-HIF pathway.

@article{Guo2011Rb1PA,
  title={Rb1 postconditioning attenuates liver warm ischemia-reperfusion injury through ROS-NO-HIF pathway.},
  author={Yingjia Lemon Guo and Tong Yang and Jun Lu and Shengfu Li and Lin Wan and Dan Long and Quansheng Li and Li Feng and Youping Li},
  journal={Life sciences},
  year={2011},
  volume={88 13-14},
  pages={598-605}
}
AIMS Ginsenoside Rb1 could prevent ischemic neuronal death and focal cerebral ischemia, but its roles to liver warm I/R injury remain to be defined. We determined if Rb1 would attenuate warm I/R injury in mice. MAIN METHODS Mice were divided into sham, I/R, Rb1+I/R (Rb1 postconditioning, 20mg/kg, i.p. after ischemia), sham+L-NAME, I/R+L-NAME, and Rb1+I/R+L-NAME groups using 60min of the liver median and left lateral lobes ischemia. Serum levels of alanine aminotransferase (ALT) were measured… CONTINUE READING
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