Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

@article{Ku2017Rb1AT,
  title={Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance},
  author={Sheng Yu Ku and Spencer R. Rosario and Yanqing Wang and Ping Mu and Mukund Seshadri and Zachary W. Goodrich and Maxwell M. Goodrich and David Labbe and Eduardo Cortes Gomez and Jianmin Wang and Henry W. Long and Bo Xu and Myles Brown and Massimo Loda and Charles L Sawyers and Leigh Ellis and David W Goodrich},
  journal={Science},
  year={2017},
  volume={355},
  pages={78-83}
}
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. Additional loss of Trp53 causes resistance to antiandrogen… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 88 times over the past 90 days. VIEW TWEETS
63 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.

ACKNOWLEDGMENTS RNA-seq data generated in this study are deposited in the Gene Expression Omnibus (accession no. GSE90891)

  • H. Hong
  • Nature 460,
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…