Rb targets histone H3 methylation and HP1 to promoters

  title={Rb targets histone H3 methylation and HP1 to promoters},
  author={Soren J. Nielsen and Robert Schneider and Uta-Maria Bauer and Andrew J. Bannister and Ashby J Morrison and D{\`o}nal O' Carroll and Ron Firestein and Michael L. Cleary and Thomas Jenuwein and Rafael E. Herrera and Tony Kouzarides},
In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein HP1 functionally interact to repress transcription at heterochromatic sites. Lysine 9 of histone H3 is methylated by SUV39H1 (ref. 2), creating a binding site for the chromo domain of HP1 (refs 3, 4). Here we show that SUV39H1 and HP1 are both involved in the repressive functions of the retinoblastoma (Rb) protein. Rb associates with SUV39H1 and HP1 in vivo by means of its pocket domain. SUV39H1 cooperates… CONTINUE READING
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