Rb protein down-regulates the stress-activated signals through inhibiting c-Jun N-terminal kinase/stress-activated protein kinase.

@article{Shim2000RbPD,
  title={Rb protein down-regulates the stress-activated signals through inhibiting c-Jun N-terminal kinase/stress-activated protein kinase.},
  author={Jung-Hyun Shim and Hyung Sun Park and Myung Jin Kim and Jihyun Park and Ellen Park and Sung Gyu Cho and Soon Ju Eom and Hyang Woo Lee and Cheol O. Joe and Eun Ju Choi},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 19},
  pages={14107-11}
}
The Rb protein is the product of the retinoblastoma susceptibility gene and loss of Rb function is detected in many types of human cancers. Rb plays important roles in the regulation of cell proliferation, differentiation, senescence, and apoptotic cell death. Here we show that Rb can physically interact with c-Jun NH(2)-terminal kinase/stress-activated protein kinase (JNK/SAPK), thereby inhibiting intracellular signals mediated by JNK/SAPK. Both in vitro binding and in vitro kinase studies… CONTINUE READING