Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).

@article{Jow2006RbET,
  title={Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).},
  author={Flora Jow and Eugene Tseng and Taneya Maddox and Ru Shen and Dianne M Kowal and John E Dunlop and Belew Mekonnen and Kewei Wang},
  journal={Assay and drug development technologies},
  year={2006},
  volume={4 4},
  pages={443-50}
}
The slow delayed rectifier K+ current, Iks, encoded by KCNQ1 (KvLQT1)/KCNE1 (mink) genes, contributes to cardiac action potential repolarization and determines the heartbeat rate. Mutations in either KCNQ1 or KCNE1 that reduce Iks cause long-QT syndrome (LQTS), a disorder of ventricular repolarization that results in cardiac arrhythmia and sudden death. A… CONTINUE READING