Raynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms

@inproceedings{Fardoun2016RaynaudsPA,
  title={Raynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms},
  author={Manal M. Fardoun and Joseph Abi Nassif and Khodr Issa and Elias A-H. Baydoun and Ali H Eid},
  booktitle={Front. Pharmacol.},
  year={2016}
}
Raynaud's phenomenon (RP) is characterized by exaggerated cold-induced vasoconstriction. This augmented vasoconstriction occurs by virtue of a reflex response to cooling via the sympathetic nervous system as well as by local activation of α2C adrenoceptors (α2C-AR). In a cold-initiated, mitochondrion-mediated mechanism involving reactive oxygen species and the Rho/ROCK pathway, cytoskeletal rearrangement in vascular smooth muscle cells orchestrates the translocation of α2C-AR to the cell… CONTINUE READING
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