Raynaud's phenomenon in mixed connective tissue disease.

  title={Raynaud's phenomenon in mixed connective tissue disease.},
  author={Thomas Grader-Beck and Fredrick Wigley},
  journal={Rheumatic diseases clinics of North America},
  volume={31 3},
  pages={465-81, vi}
Raynaud's phenomenon affects most patients who have mixed connective tissue disease (MCTD) and frequently represents the initial manifestation of the disease. It is the cutaneous symptom of a systemic vasculopathy that is characterized by intimal fibrosis and blood vessel obliteration that frequently leads to visceral involvement, particularly pulmonary hypertension. An association between Raynaud's phenomenon and the characteristic autoantibody in MCTD, anti-U1-RNP (ribonucleoprotein), is… CONTINUE READING
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