• Corpus ID: 29630901

Rauwolfia Serpentina Ameliorates Hyperglycemic, Haematinic and Antioxidant Status in Alloxan- Induced Diabetic Mice

@inproceedings{Azmi2013RauwolfiaSA,
  title={Rauwolfia Serpentina Ameliorates Hyperglycemic, Haematinic and Antioxidant Status in Alloxan- Induced Diabetic Mice},
  author={Muhammad Bilal Azmi and Shamim A Qureshi},
  year={2013}
}
To investigate the effect of methanolic root extract (MREt) of Rauwolfia serpentina on hyperglycemic, haematinic and antioxidative dysfunction associated with alloxan-induced diabetes. Mice were divided into normal and alloxan-induced diabetic groups, the second group was sub-divided into three MREt (10, 30 & 60mg/kg) treated test groups and three diabetic (distilled water 1ml/kg), negative (0.05% dimethyl sulphoxide 1ml/kg) and positive (glibenclamide 5mg/kg) control groups. Each treatment was… 
japsonline.com
9 Citations
Background Citations
3
Methods Citations
3

Figures from this paper

9 Citations

Citation Type

Citation Type

Methanolic Root Extract of Rauwolfia serpentina Lowers Atherogenic Dyslipidemia, Arteriosclerosis and Glycosylation Indices in Type 1 Diabetic Mice.
TLDR
The obtained results indicated the therapeutic potential of MREt in lowering the risk of atherogenic dyslipidemia, arteriosclerosis and glycosylation in alloxan-induced type 1 diabetic mice.
Therapeutic role of Rauwolfia serpentina in minimizing the risk of glycosylation and associated biomarkers in experimentally induced type 1 diabetic mice.
TLDR
Administration of test doses of HyMREt were significantly reduced the glycosylation, oxidative stress and anemia caused by alloxan intoxication in mice.
Ameliorative effect of hydro-methanolic extract from roots of Rauwolfia serpentina on some biochemical parameters of type 1 diabetic mice.
TLDR
Findings of present study support the hypoglycemic and hypolipidemic potential of HyMREt of R. serpentina in type 1 (alloxan induced) diabetic mice.
Centratherum anthelminticum seeds reverse the carbon tetrachloride-induced hepatotoxicity in rats
TLDR
The ESEt was found to be hepatoprotective and antioxidative in nature and proved the liver regenerating property of ESET by showing decrease in fatty deposition, necrosis and inflammation around the central vein of liver lobules.
Genus Rauvolfia: A review of its ethnopharmacology, phytochemistry, quality control/quality assurance, pharmacological activities and clinical evidence.
THERAPEUTIC REVIEW ON PANDUHARADRAVYAS (DRUGS FOR ANAEMIA) FROM NIGHANTUS
TLDR
135 drugs were reported to their Pandu combatting action in different 15 Nighantus, which includes 70 herbal, 28 mineral, 15 animal origin drugs and 22 are other drugs, whose reported haematinic activities were reviewed from available literature.
In silico investigation on alkaloids of Rauwolfia serpentina as potential inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA reductase
Reserpine-Induced Depression and Other Neurotoxicity: A Monoaminergic Hypothesis
STUDIES ON SOME POTENTIAL MEDICINAL PLANTS AS AN ALTERNATIVE TREATMENT IN REDUCING THE RISK OF DIABETIC COMPLICATIONS

References

SHOWING 1-10 OF 24 REFERENCES
Antidiabetic and haematinic effects of Parquetina nigrescens on alloxan induced type-1 diabetes and normocytic normochromic anaemia in Wistar rats
TLDR
Parquetina nigrescens demonstrated antidiabetic property by reducing the elevated blood glucose in alloxan treated rats which is comparable to animals that received the standard drug.
Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice
TLDR
MREt improves the glycemic, antiatherogenic, coronary risk, and cardioprotective indices in alloxan-induced diabetic mice and is effective in improving the body weights, glucose and insulin levels, insulin/glucose ratio, glycosylated and total hemoglobin in test groups as compared to diabetic control.
Methanolic Root Extract of Rauwolfia serpentina Improves the Glucose Tolerance in Wister Mice
TLDR
The results indicated that the MREt (10 - 60 mg/kg) was non-sedative and effective in lowering the blood glucose level in mice but showed lethal effect in terms of sedation and mortality at doses ≥ 100mg/kg, therefore, MRET of R. serpentina in small doses can improve the glucose tolerance either at pancreatic or extra-pancreatic level.
Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice.
TLDR
It is suggested that berberine administration in vivo protects pancreatic islets and serum lipids in NOD mice.
Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats
  • L. Pari, M. Latha
  • Biology, Medicine
    BMC complementary and alternative medicine
  • 2004
TLDR
Both the treated groups showed significant decrease in TBARS and hydroperoxides formation in brain, suggesting its role in protection against lipidperoxidation induced membrane damage, suggesting a possible antiperoxidative role for Scoparia dulcis plant extract.
Anti-diabetic and some haematological effects of ethylacetate and n-butanol fractions of Indigofera pulchra extract on alloxan-induced diabetic Wistar rats
TLDR
Both ethylacetate and n-butanol fractions of I.pulchra extract were found to have potent anti-diabetic effects.
In Vitro and In Vivo Antioxidant Potential of Hydromethanolic Extract of Phoenix dactylifera Fruits
TLDR
The results obtained in the present study indicate that the Phoenix dactylifera fruit is a potential source of natural antioxidant and free radical scavenging and antioxidant activities.
Phytochemical based strategies for pathogen control and Antioxidant Capacities of Rauwolfia serpentina Extracts
TLDR
From the results it is clear that Rauwolfia serpentina contains a variety of compounds with confirmed antioxidant capacity and other putative health benefits relating to the prevention or treatment of diabetes, cardiovascular disease, cancer and hypertension, hence justifying its use for biological in vivo efficacy studies.
Ethnobotanical aspects of Rauvolfia serpentina (L). Benth. ex Kurz. in India, Nepal and Bangladesh
TLDR
The present review deals with the extensive amount of work undertaken in recent years at different parts of the Indian subcontinent to explore the use of this plant in the treatment of different ailments by the tribals or the aboriginals as a part of their ethnomedical system.
A Review of Recent Investigations on Medicinal Herbs Possessing Anti-Diabetic Properties
TLDR
The paper reviews composition, active principles and pharmacological effects of some important plants which are widely used in commercially available herbal and polyherbal formulations and provides a detailed list of plants reported to possess potential anti-diabetic activity.
...
1
2
3
...