Rattlesnake venom induces apoptosis by stimulating PC-PLC and upregulating the expression of integrin beta4, P53 in vascular endothelial cells.

@article{Zhao2004RattlesnakeVI,
  title={Rattlesnake venom induces apoptosis by stimulating PC-PLC and upregulating the expression of integrin beta4, P53 in vascular endothelial cells.},
  author={Qitao Zhao and Satohiko Araki and Shangli Zhang and Jun-ying Miao},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2004},
  volume={44 2},
  pages={161-8}
}
In the previous studies, we found that phosphatidylcholine-specific phospholipase C (PC-PLC) was implicated in apoptosis induced by rattlesnake venom in vascular endothelial cells (VEC) [Biochem. Biophys. Res. Commun. (1997b) 223, 182]. In order to find out other signal elements in this pathway and the mechanisms by which PC-PLC mediates apoptosis induced by rattlesnake venom in VEC, the expression of integrin beta4 and P53 was evaluated when the activity of PC-PLC was suppressed by D609… CONTINUE READING

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