Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ

@article{Devine1996RatsRD,
  title={Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ},
  author={Darragh P. Devine and Larry D. Taylor and Rainer K Reinscheid and Frederick J. Monsma and Olivier Civelli and Huda Akil},
  journal={Neurochemical Research},
  year={1996},
  volume={21},
  pages={1387-1396}
}
We examined the effects of intracerebroventricular (i.c.v.) administration of orphanin FQ (OFQ) on locomotor activity in rats. The rats were habituated to locomotor-testing boxes and then injected i.c.v. with OFQ (0–10 nmoles). Acute injections of OFQ produced dose-orderly reductions in horizontal locomotion and rearing activity. This suppression of motor activity was characterized by a disruption of balance and muscle control. Within minutes of i.c.v. injection of the higher doses of OFQ, the… CONTINUE READING
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