Rats become acutely tolerant to cathine after amphetamine or cathinone administration

@article{Schechter2005RatsBA,
  title={Rats become acutely tolerant to cathine after amphetamine or cathinone administration},
  author={Martin D. Schechter},
  journal={Psychopharmacology},
  year={2005},
  volume={101},
  pages={126-131}
}
  • M. Schechter
  • Published 2005
  • Psychology, Medicine
  • Psychopharmacology
The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kgd-amphetamine or 0.8 mg/kgl-cathinone to generalize to 2.4–6.0 mg/kg of the active cathinone metabolited-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n=6) trained with cathinone (ED50=3.03 mg/kg) and in rats (n=8) trained with amphetamine (ED50=2.93 mg/kg). In contrast, when… Expand
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