Ratios of radical to conservative amino acid replacement are affected by mutational and compositional factors and may not be indicative of positive Darwinian selection.

Abstract

The ratio of radical to conservative amino acid replacements is frequently used to infer positive Darwinian selection. This method is based on the assumption that radical replacements are more likely than conservative replacements to improve the function of a protein. Therefore, if positive selection plays a major role in the evolution of a protein, one… (More)

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@article{Dagan2002RatiosOR, title={Ratios of radical to conservative amino acid replacement are affected by mutational and compositional factors and may not be indicative of positive Darwinian selection.}, author={Tal Dagan and Yael Talmor and Dan Graur}, journal={Molecular biology and evolution}, year={2002}, volume={19 7}, pages={1022-5} }