Rationally-designed logic integration of regulatory signals in mammalian cells

  title={Rationally-designed logic integration of regulatory signals in mammalian cells},
  author={Madeleine Leisner and Leonidas Bleris and Jason Lohmueller and Zhen Xie and Yaakov Benenson},
  booktitle={Nature nanotechnology},
Molecular-level information processing is essential for 'smart' in vivo nanosystems. Natural molecular computing, such as the regulation of messenger RNA (mRNA) synthesis by special proteins called transcription factors, has inspired engineered systems that can control the levels of mRNA with certain combinations of transcription factors. Here, we show an alternative approach to achieving general-purpose control of mRNA and protein levels by logic integration of transcription factor input… CONTINUE READING

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