Rationally designed families of orthogonal RNA regulators of translation.

@article{Mutalik2012RationallyDF,
  title={Rationally designed families of orthogonal RNA regulators of translation.},
  author={Vivek K. Mutalik and Honglei Liu and Joao C. Guimaraes and Julius B. Lucks and Adam Paul Arkin},
  journal={Nature chemical biology},
  year={2012},
  volume={8 5},
  pages={
          447-54
        }
}
Our ability to routinely engineer genetic networks for applications is limited by the scarcity of highly specific and non-cross-reacting (orthogonal) gene regulators with predictable behavior. Though antisense RNAs are attractive contenders for this purpose, quantitative understanding of their specificity and sequence-function relationship sufficient for their design has been limited. Here, we use rationally designed variants of the RNA-IN-RNA-OUT antisense RNA-mediated translation system from… CONTINUE READING
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