Rationalization and prediction of drug resistant mutations in targets for clinical anti-tubercular drugs.

@article{Padiadpu2013RationalizationAP,
  title={Rationalization and prediction of drug resistant mutations in targets for clinical anti-tubercular drugs.},
  author={Jyothi Padiadpu and Sumanta Mukherjee and Nagasuma R. Chandra},
  journal={Journal of biomolecular structure & dynamics},
  year={2013},
  volume={31 1},
  pages={
          44-58
        }
}
Resistance to therapy limits the effectiveness of drug treatment in many diseases. Drug resistance can be considered as a successful outcome of the bacterial struggle to survive in the hostile environment of a drug-exposed cell. An important mechanism by which bacteria acquire drug resistance is through mutations in the drug target. Drug resistant strains (multi-drug resistant and extensively drug resistant) of Mycobacterium tuberculosis are being identified at alarming rates, increasing the… CONTINUE READING
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