Rationale for the use of somatostatin analogs as antitumor agents.

  title={Rationale for the use of somatostatin analogs as antitumor agents.},
  author={Christiane Susini and Louis Buscail},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={17 12},
BACKGROUND There is a need for novel antitumor agents that demonstrate efficacy in currently refractory tumors without adding to the toxicity of therapy. The somatostatin analogs, which have demonstrated antineoplastic activities in experimental tumor models, and good tolerability and safety profiles are attractive candidates. MATERIALS AND METHODS Data from preclinical studies provide evidence for direct and indirect mechanisms by which somatostatin analogs exert antitumor effects. RESULTS… CONTINUE READING
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