Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis.

@article{Gray2006RationaleFT,
  title={Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis.},
  author={Steven G Gray and Fernando Dangond},
  journal={Epigenetics},
  year={2006},
  volume={1 2},
  pages={67-75}
}
Major recent advances in the field of chromatin remodeling have dramatically changed our understanding of the ways in which genes are regulated. Epigenetic regulators such as histone deacetylases (HDACs) and histone acetyltransferases (HATs) are increasingly being implicated as direct or indirect components in the regulation of expression of neuronal, immune and other tissue specific genes. HDACs and HATs have been shown to play important roles in cell growth, cell cycle control, development… CONTINUE READING

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