Rationale for the application of RANKL inhibition in the treatment of Langerhans cell histiocytosis.


CONTEXT Langerhans Cell Histiocytosis (LCH) is a rare disease exhibiting both neoplastic and inflammatory features including abundant cytokine secretion both at the lesional and systemic level. OBJECTIVE Evaluation of RANKL expression within LCH lesions in various tissues. DESIGN Cross-sectional study involving paraffin blocks from the diagnostic… (More)
DOI: 10.1210/jc.2014-2654