Rationale for maintenance of the M184v resistance mutation in human immunodeficiency virus type 1 reverse transcriptase in treatment experienced patients.

@article{Turner2004RationaleFM,
  title={Rationale for maintenance of the M184v resistance mutation in human immunodeficiency virus type 1 reverse transcriptase in treatment experienced patients.},
  author={Dan Turner and Bluma G Brenner and Jean Pierre Routy and Marco Petrella and Mark A. Wainberg},
  journal={The new microbiologica},
  year={2004},
  volume={27 2 Suppl 1},
  pages={31-9}
}
The M184V substitution in HIV-1 RT develops rapidly following initiation of therapy with 3TC and confers high-level phenotypic resistance to this drug both in vitro and in vivo. Interestingly, the presence of M184V is also associated with alteration of several mechanisms relating to RT function that include decreased RTprocessivity, reduced nucleotide-dependent primer unblocking, increased fidelity, hypersensitization to other NRTIs, impaired viral fitness, and delayed appearance of mutations… CONTINUE READING

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