Rationale for investigating metformin as a protectant against statin-associated muscle symptoms.

Abstract

The mechanisms underlying statin-associated muscle symptoms (SAMS) are not understood. Mitochondrial dysfunction and atrogin-1 activation are among the leading possible explanations for SAMS. Interestingly, metformin can enhance mitochondrial function and may affect atrogin-1 expression. Therefore, we sought to perform a systematic search of the literature… (More)
DOI: 10.1016/j.jacl.2017.06.019

Topics

Cite this paper

@article{Elsaid2017RationaleFI, title={Rationale for investigating metformin as a protectant against statin-associated muscle symptoms.}, author={Ossama Elsaid and Beth L Taylor and Amanda L. Zaleski and Gregory A. Panza and Paul Daniel Thompson}, journal={Journal of clinical lipidology}, year={2017}, volume={11 5}, pages={1145-1151} }