Rationale for inhibition of the hedgehog pathway paracrine loop in pancreatic adenocarcinoma.

@article{Dimou2011RationaleFI,
  title={Rationale for inhibition of the hedgehog pathway paracrine loop in pancreatic adenocarcinoma.},
  author={Anastasios T Dimou and Konstantinos Syrigos and Muhammad Wasif Saif},
  journal={JOP : Journal of the pancreas},
  year={2011},
  volume={12 1},
  pages={1-5}
}
The role of hedgehog pathway in the biology of pancreatic adenocarcinoma is an emerging area of investigation and provides a novel field for treatment intervention. Recent studies have shown the activation of the hedgehog pathway in pancreatic cancer. Despite the initial assumption of an autocrine mechanism, it seems that the hedgehog pathway contributes to… CONTINUE READING