Rationale for chemoradiotherapy

  title={Rationale for chemoradiotherapy},
  author={Yasumasa Nishimura},
  journal={International Journal of Clinical Oncology},
The rationale for combining chemotherapy (CT) and radiotherapy (RT) is based mainly on two ideas, one being spatial cooperation and the other the enhancement of radiation effects. Spatial cooperation is effective if CT is sufficiently active to eradicate subclinical metastases and if the primary local tumor is effectively treated by RT. In this regard, no interaction between RT and CT is required, but differing toxicities are needed so that both modalities can be used at effective dosages. To… CONTINUE READING


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