Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases

@inproceedings{AlonsoRamrez2010RationaleFT,
  title={Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases},
  author={Ruby Alonso-Ram{\'i}rez and S{\'e}verine Loisel and Caroline Buors and Jacques-Olivier Pers and E Montero and Pierre Youinou and Yves Renaudineau},
  booktitle={Arthritis},
  year={2010}
}
CD6 is a 105-130 kDa surface glycoprotein expressed on the majority of T cells and a subset of B cells. The human cd6 gene maps to chromosome 11, and the expression of its protein product is tightly regulated. CD6 mediates cellular adhesion migration across the endothelial and epithelial cells. In addition, it participates in the antigen presentation by B cells and the subsequent proliferation of T cells. CD6 may bind in trans to surface glycoproteins (such as ALCAM and 3A11), or to microbial… CONTINUE READING
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