Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy.

@article{Brennen2012RationaleBT,
  title={Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy.},
  author={W Nathaniel Brennen and John T Isaacs and Samuel R Denmeade},
  journal={Molecular cancer therapeutics},
  year={2012},
  volume={11 2},
  pages={257-66}
}
The tumor microenvironment has emerged as a novel chemotherapeutic strategy in the treatment of cancer. This is most clearly exemplified by the antiangiogenesis class of compounds. Therapeutic strategies that target fibroblasts within the tumor stroma offer another treatment option. However, despite promising data obtained in preclinical models, such strategies have not been widely used in the clinical setting, largely due to a lack of effective treatments that specifically target this… CONTINUE READING
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